ISSN:
1432-2242
Keywords:
Linkage analysis
;
Bayesian method
;
Markov chain Monte Carlo
;
Quantitative-trait loci
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract A Bayesian approach to the statistical mapping of Quantitative Trait Loci (QTLs) using single markers was implemented via Markov Chain Monte Carlo (MCMC) algorithms for parameter estimation and hypothesis testing. Parameter estimators were marginal posterior means computed using a Gibbs sampler with data augmentation. Variables sampled included the augmented data (marker-QTL genotypes, polygenic effects), an indicator variable for linkage, and the parameters (allele frequency, QTL substitution effect, recombination rate, polygenic and residual variances). Several MCMC algorithms were derived for computing Bayesian tests of linkage, which consisted of the marginal posterior probability of linkage and the marginal likelihood of the QTL variance associated with the marker.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00230141
