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  • 1
    ISSN: 1573-904X
    Keywords: trilostane ; ketotrilostane ; reversible metabolism ; pharmacokinetics ; metabolic interconversion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The pharmacokinetics of trilostane and one of its metabolites ketotrilostane are described and characterized in the rat following the separate intravenous administration of trilostane and ketotrilostane. It was noted during these studies that the parent compound and its metabolite undergo metabolic interconversion–trilostane producing ketotrilostane and ketotrilostane generating trilostane. This result means that trilostane is conserved in the body by interconversion-being metabolized to ketotrilostane and then subsequently back to the “parent” drug, trilostane.
    Type of Medium: Electronic Resource
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