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Skin Structure and Metabolism: Relevance to the Design of Cutaneous Therapeutics (1984)

Bucks, Daniel A. W.

Springer

Pharmaceutical research 1 (1984), S. 148-153

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ISSN: 1573-904X

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Abstract The outer layer of the epidermis or stratum corneum is the major barrier to percutaneous absorption. It has been shown that there are numerous enzyme systems beneath the stratum corneum in the viable epidermis capable of metabolizing drugs. A number of prodrug and soft drug topical therapeutic agents have been designed. After these agents penetrate the stratum corneum, they are metabolized by the cutaneous esterase systems to the desired metabolites.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1023/A:1016340423079

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