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Secretion of lysosomal enzymes by human placental villi in vitro (1980)

Douglas, Gordon C. ; Mackenzie, Alan

Springer

Molecular and cellular biochemistry 33 (1980), S. 93-96

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ISSN: 1573-4919

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Chemistry and Pharmacology , Medicine

Notes: Summary Chorionic villi from first trimester and term human placentas have been incubated in vitro and shown to release the lysosomal enzymes, β-hexosaminidase, α-glucosidase and β-gluctlronidase. There was negligible release of the cytoplasmic enzyme, lactate dehydrogenase, under the same conditions. The first trimester villi released proportionally more of their lysosomal enzyme content than did the term villi. Extracellular levels of β-hexosaminidase were raised and those of α-glucosidase and, β-glucuronidase were lowered when tissue was incubated with 1 μM colchicine, suggesting that microtubules are involved in the control of lysosomal enzyme release from placental villi.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00224573

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