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Molecular location of the genetic lesion in the acatalasemic mouse (1972)

Feinstein, Robert N. ; Jaroslow, Bernard N. ; Howard, Judith B.

Springer

Biochemical genetics 6 (1972), S. 263-273

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ISSN: 1573-4927

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Chemistry and Pharmacology

Notes: Abstract Antibody to normal mouse catalase will stabilize blood and liver catalase of the acatalasemic mouse against a variety of agents which damage protein tertiary structure (urea, guanidine, trypsin) but not against agents which affect the heme group (azide, hydroxylamine). The antibody will also stabilize catalase against inhibition by 3-amino 1,2,4-triazole (AT), the specific site of action of which is known. The antibody is able also to protect normal mouse catalase from urea denaturation, but it is without effect on AT inhibition of normal catalase. A hypothesis is proposed which explains these results and which helps localize the site of the mutation on the catalase molecule.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00486120

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