ISSN:
1573-1111
Keywords:
Terfenadine
;
β-cyclodextrin
;
inclusion complex
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Terfenatine (TFN) is a very hydrophobic antiallergic drug. It exists in three polymorphic and two solvated forms and is practically insoluble in water. These properties make a pharmaceutical formulation with acceptable biopharmaceutical characteristics difficult to prepare. Inclusion complexation with β-cyclodextrin (βCD) may eliminate such problems. The properties of the TFN/βCD system have been studied in liquid, gaseous and solid phases by1H and13C NMR spectroscopy, powder X-ray diffractometry, differential scanning calorimetry and fast atom bombardment mass spectrometry. The solubility phase diagram was also recorded. In solution and in the gaseous phase the 1∶1 complex prevails, whereas a 1∶2 TFN/βCD complex has been isolated by precipitation from homogeneous solution.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00709073
