ISSN:
1420-9071
Keywords:
Mitochondria
;
mitochondrial inheritance
;
cytoskeleton
;
Saccharomyces cerevisiae
;
Schizosaccharomyces pombe
;
membrane proteins
;
organelle movement
;
mitochondrial morphology
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Mechanisms mediating the inheritance of mitochondria are poorly understood, but recent studies with the yeastsSaccharomyces cerevisiae andSchizosaccharomyces pombe have begun to identify components that facilitate this essential process. These components have been identified through the analysis of conditional yeast mutants that display aberrant mitochondrial distribution at restrictive conditions. The analysis of these mutants has uncovered several novel proteins that are localized either to cytoskeletal structures or to the mitochondria themselves. Many mitochondrial inheritance mutants also show altered mitochondrial morphology and defects in maintenance of the mitochondrial genome. Although some inheritance components and mechanisms appear to function specifically in certain types of cells, other conserved proteins are likely to mediate mitochondrial behavior in all eukaryotic cells.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01952109
