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Reversible impairment of hepatobiliary function induced by streptozotocin in the rat (1984)

Carnovale, C. E. ; Garay, E. A. Rodriguez

Springer

Cellular and molecular life sciences 40 (1984), S. 248-250

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ISSN: 1420-9071

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary The effect of streptozotocin (SZ) on hepatobiliary function was studied in rats on the 1st, 7th and 15th days of treatment. Serum glucose increased significantly on the 1st day, and then remained high. Bile flow, bile acids output and BSP biliary excretion were significantly decreased on the 1st day of treatment, whereas serum sorbitol dehydrogenase was increased. All the parameters tested apart from serum glucose tended to normalize with time. The results suggested a transient toxic effect of SZ on the hepatocyte.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01947564

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