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Neuronal cell deficits following maternal exposure to methadone in rats (1982)

Zagon, I. S. ; McLaughlin, Patricia J.

Springer

Cellular and molecular life sciences 38 (1982), S. 1214-1216

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ISSN: 1420-9071

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary Rat offspring were maternally subjected to methadone hydrochloride during gestation or lactation. At 21 days of age, the area of the pyramis (cerebellar lobule VIII) in prenatally and postnatally exposed groups was reduced 45% and 36%, respectively, from control levels, and the total number of internal granule neurons/section was reduced 49% and 46%, respectively; the number of granule neurons/mm2 in both groups was 75% of control values. Based on histological evaluation the timetable of cerebellar morphogenesis was unaltered in rats prenatally exposed to methadone, suggesting a permanent neuronal deficit, but cerebellar development was markedly delayed in animals subjected postnatally.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01959747

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