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  • 1
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 66 (1983), S. 2454-2466 
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Molecular catalysis of ATP-hydrolysis by a number of protonated macrocyclic polyamines 1-9 has been investigated by 31P-NMR spectroscopy, and marked rate enhancements have been obtained. The largest acceleration is produced by the [24]-N6O2 macrocycle 1, and the process displays the following properties: 1. protonated 1 forms very stable complexes with ATP, as well as with ADP and AMP; 2. it enhances the rate of ATP-hydrolysis by a factor of 103 at pH = 8.5; the rate of hydrolysis is constant over a wide pH-range, from pH = 2.5 to 8.5; 3. 1 is more efficient than acyclic analogues; 4. the products of the reaction are orthophosphate (OP) and ADP, which is subsequently hydrolyzed to OP and AMP at a slower rate; 5. at pH 〉 6.5, a transient species is detected, which is tentatively identified as a phosphoramidate intermediate, resulting from phosphorylation of the macrocycle 1; 6. the reaction presents first-order kinetics and is catalytic. The mechanism of the process is discussed in terms of initial formation of a complex between ATP and protonated 1, followed by an intracomplex reaction which may involve a combination of nucleophilic or acid catalysis with electrostatic catalysis.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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