ISSN:
0268-2605
Keywords:
lanthanum
;
asymmetric catalyst
;
bimetallic catalyst
;
nitroaldol
;
ß-blockers
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The La-Li-(R)-BINOL complex prepared from either lanthanum(III) chloride [LaCl3 · 7H2O] or [La(O-i-Pr)3] has made possible effective catalytic asymmetric syntheses of therapeutically important ß-blockers such as propranolol and metoprolol. The possible stereochemical course of asymmetric nitroaldol reactions has been also clarified.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/aoc.590090508