ISSN:
0170-2041
Keywords:
3-Amino-4-hydroxyhexahydroazepine
;
Cordyceps ophioglossoides
;
Antifungals
;
Antibiotics
;
Ophiocordin
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
(3R,4R)-3-Amino-4-hydroxyhexahydroazepine (2), the optically active constituent of the antifungal antibiotic ophiocordin (1), was prepared in a multistep synthesis starting from D-serine. The absolute configuration was unambigously assigned by a comparison of the synthesized stereoisomer 2 with its racemate and the chiral moiety of the antibiotic ophiocordin by enantioselective gas chromatography.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.1993199301106