Wiley InterScience Backfile Collection 1832-2000
Chemistry and Pharmacology
Enzyme-Catalyzed Reactions, 8. - Stereoselective Synthesis of 2-Amino Alcohols from (R)- and (S)-Cyanohydrinserythro-2-Amino alcohols (1R,2S)- and (1S,2R)-4 may be synthesized stereoselectively by addition of Grignard compounds to cyanohydrins (R)-, (S)-1 and their O-trimethylsilyl derivatives 3, respectively, followed by hydrogenation. The threo-2-amino alcohols (1S,2S)- and (1R,2R)-4 are easily accessible by inversion at C-1 of the (1R,2S) and (1S,2R) compounds.
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