ISSN:
1434-1948
Keywords:
Dihydroxybiphenyl
;
Iron chelation
;
Formation constants
;
Protonation constants
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A new water-soluble iron(III) sequestering agent has been designed. The tris-bidentate tripodal ligand consists of three 2,2′-dihydroxybiphenyl subunits connected via amide linkages at their meta (4-) positions to a framework of the “tren” type. The key step of the synthesis involves the coupling of suitably substituted monophenyl moieties in order to obtain the biphenyl precursor. The deprotonation constants of the ligand, and the formation and deprotonation constants of the FeIII complex have been determined from potentiometric and spectrophotometric measurements. The results are compared with those of a previously described homologous ligand in which the chelating subunits are attached to the tren framework via the ortho (3-) position of the biphenyl rather than the 4-position.
Type of Medium:
Electronic Resource
