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Movement of myosin-coated structures on actin cables (1983)

Sheetz, Michael P. ; Spudich, James A.

New York, NY : Wiley-Blackwell

Cell Motility and the Cytoskeleton 3 (1983), S. 485-489

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ISSN: 0886-1544

Keywords: cell motility ; myosin ; actin ; vesicle transport ; Life and Medical Sciences ; Cell & Developmental Biology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Medicine

Notes: Myosin-coated spheres from 0.6 to 120 μm in diameter move in vitro on a substratum of polar arrays of actin cables derived from the alga Nitella. The force for this movement is provided by skeletal muscle myosin since it is ATP-dependent, and N-ethylmaleimide (NEM) inactivation of the myosin blocks movement. These observations demonstrate that attachment of myosin in a random orientation to structures will enable those structures to move along polar arrays of actin filaments.

Additional Material: 2 Ill.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1002/cm.970030515

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