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XY female mice express H-Y antigen (1982)

Johnson, Lawrence L. ; Sargent, Evelyn L. ; Washburn, Linda L. ; [et al.]

Chichester [u.a.] : Wiley-Blackwell

Developmental Genetics 3 (1982), S. 247-253

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ISSN: 0192-253X

Keywords: H-Y antigen ; sex determination ; Life and Medical Sciences ; Genetics

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology

Notes: Karyotypically XY individuals of the C57BL/6J-YPOS mouse stock develop as females or hermaphrodites, but never as normal males. The aberrant sexual development results from the interaction of the C57BL/6J genetic background with the M. poschiavinus-derived Y chromosome. XY females from this stock were assayed for H-Y antigen. By the criteria of skin-grafting, the cell-mediated lympholysis test, and the popliteal lymph node assay, these XY females are antigenically indistinguishable from normal C57BL/6 males. Implications for the hypothesis that H-Y antigen induces formation of the mammalian testis are discussed.

Additional Material: 2 Tab.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1002/dvg.1020030307

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