ISSN:
0935-6304
Keywords:
Gas chromatography/mass spectrometry
;
Capillary, fused silica
;
Negative ion
;
Femtogram sensitivity
;
Nitroglycerin
;
Organic nitrates
;
Dinitroglycerin
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Recent developments in the use of negative ion detection in GC-MS have indicated the potential for highly sensitive analyses for certain compounds. This paper describes the application of the techniques to the assay of Nitroglycerin and its metabolites yielding sensitivity to two femtograms. Because of the low levels of nitroglycerin in biological media such sensitivity is highly desirable if not essential for meaningful measurements. In addition to sensitivity the method is shown to yield extremely good selectivity contributing further to the credibility of quantitative results.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jhrc.1240060204
