Publikationsdatum:
1998-01-07
Beschreibung:
A Sonic hedgehog (Shh) response element was identified in the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) promoter that binds to a factor distinct from Gli, a gene known to mediate Shh signaling. Although this binding activity is specifically stimulated by Shh-N (amino-terminal signaling domain), it can also be unmasked with protein phosphatase treatment in the mouse cell line P19, and induction by Shh-N can be blocked by phosphatase inhibitors. Thus, Shh-N signaling may result in dephosphorylation of a target factor that is required for activation of COUP-TFII-, Islet1-, and Gli response element-dependent gene expression. This finding identifies another step in the Shh-N signaling pathway.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krishnan, V -- Pereira, F A -- Qiu, Y -- Chen, C H -- Beachy, P A -- Tsai, S Y -- Tsai, M J -- New York, N.Y. -- Science. 1997 Dec 12;278(5345):1947-50.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030 USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9395397" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Animals
;
COUP Transcription Factor II
;
COUP Transcription Factors
;
Cell Line
;
DNA/metabolism
;
DNA-Binding Proteins/*genetics/metabolism
;
Enzyme Inhibitors/pharmacology
;
*Gene Expression Regulation
;
Hedgehog Proteins
;
Mice
;
Okadaic Acid/pharmacology
;
Oxazoles/pharmacology
;
Phosphoprotein Phosphatases/antagonists & inhibitors/*metabolism
;
Phosphorylation
;
Promoter Regions, Genetic
;
Proteins/*genetics/*metabolism
;
*Receptors, Steroid
;
Signal Transduction
;
*Trans-Activators
;
Transcription Factors/*genetics/metabolism
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
