Publikationsdatum:
1995-04-14
Beschreibung:
A fundamental question in signal transduction is how stimulation of a specific protein kinase leads to phosphorylation of particular protein substrates throughout the cell. Recent studies indicate that specific anchoring proteins located at various sites in the cell compartmentalize the kinases to their sites of action. Inhibitors of the interactions between kinases and their anchoring proteins inhibit the functions mediated by the kinases. These data indicate that the location of these anchoring proteins provides some of the specificity of the responses mediated by each kinase and suggest that inhibitors of the interaction between the kinases and their anchoring proteins may be useful as therapeutic agents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mochly-Rosen, D -- R01 HL-43380/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1995 Apr 14;268(5208):247-51.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Pharmacology, School of Medicine, Stanford University, CA 94305-5332, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7716516" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Animals
;
*Cell Compartmentation
;
Cell Membrane/metabolism
;
Cytoskeleton/metabolism
;
Humans
;
Protein Kinases/*metabolism
;
Proteins/*metabolism
;
*Signal Transduction
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
