Publikationsdatum:
1978-02-03
Beschreibung:
The clonal proliferation of the committed granulocyte-macrophage stem cell is controlled by a balance between mutually opposing factors, colony stimulating factor and prostaglandin E, both of monocyte-macrophage derivation. Increases beyond a critical concentration of colony stimulating factor within the local milieu of the mononuclear phagocyte induces the coincident elaboration of prostaglandin E, a self-regulated response which serves to limit the unopposed humoral stimulation of myelopoiesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kurland, J I -- Bockman, R S -- Broxmeyer, H E -- Moore, M A -- New York, N.Y. -- Science. 1978 Feb 3;199(4328):552-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/304600" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Animals
;
Bone Marrow Cells
;
Cell Differentiation
;
Cells, Cultured
;
Colony-Stimulating Factors/*physiology
;
Feedback
;
Glycoproteins/*physiology
;
Granulocytes/*cytology
;
*Hematopoiesis
;
Humans
;
Leukocytes/*cytology
;
Macrophages/cytology/*physiology
;
Mice
;
Models, Biological
;
Monocytes/*physiology
;
Prostaglandins E/*physiology
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
