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Viscous control of cellular respiration by membrane lipid composition (2018)

Budin, I., de Rond, T., Chen, Y., Chan, L. J. G., Petzold, C. J., Keasling, J. D.

American Association for the Advancement of Science (AAAS)

In: Science First Release

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Publikationsdatum: 2018

Beschreibung: 〈p〉Lipid composition determines the physical properties of biological membranes and can vary substantially between and within organisms. We describe a specific role for the viscosity of energy-transducing membranes in cellular respiration. Engineering of fatty acid biosynthesis in 〈i〉Escherichia coli〈/i〉 allowed us to titrate inner membrane viscosity across a 10-fold range by controlling the abundance of unsaturated or branched lipids. These fluidizing lipids tightly controlled respiratory metabolism, an effect that can be explained with a quantitative model of the Electron Transport Chain (ETC) that features diffusion-coupled reactions between enzymes and electron carriers (quinones). Lipid unsaturation also modulated mitochondrial respiration in engineered budding yeast strains. Thus, diffusion in the ETC may serve as an evolutionary constraint for lipid composition in respiratory membranes.〈/p〉

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Allgemeine Naturwissenschaft

Publiziert von American Association for the Advancement of Science (AAAS)

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