Publication Date:
2018-01-01
Description:
This study investigated associations between SNPs in genes encoding metabolizing drug enzymes and laboratory parameters in sickle cell anemia patients under hydroxyurea (SCA-HU+). We evaluated hematologic and biochemical parameters by electronic methods and SNPs by PCR-RFLP and multiplex PCR in 35 SCA-HU+patients and 67 SCA-HU−patients. The HbS, total cholesterol, lactate dehydrogenase, aspartate aminotransferase, total bilirubin and fractions levels, and leukocyte, eosinophil, monocyte, and erythroblast counts were reduced in SCA-HU+patients (pC/−1053C〉T were higher in SCA-HU+patients (pA,CYP2E1−1293G〉C/−1053C〉T, andGSTT1can be associated with alterations in lipid, inflammatory, renal, hemolytic, and hepatic profiles. However, further studies are needed to elucidate these associations.
Print ISSN:
0278-0240
Electronic ISSN:
1875-8630
Topics:
Biology
,
Chemistry and Pharmacology