Publication Date:
2007-11-16
Description:
Background: γ’ fibrinogen is a newly-emerging cardiovascular disease (CVD) biomarker that has shown significant associations with coronary artery disease in small case/control studies. γ’ fibrinogen is an isoform with an altered γ chain, and constitutes ∼10% of total fibrinogen. Both elevated γ’ and total fibrinogen cause fibrinolytic resistance in vitro. However, data are lacking from community based studies on the association of γ’ fibrinogen with CVD risk factors or with clinical CVD. Methods: γ’ fibrinogen levels were measured using an ELISA assay in 3284 men and women in the Framingham Heart Study Offspring Cohort 7th examination cycle (2002–05). Associations of γ’ fibrinogen were examined using linear regression for continuous CVD risk factors and logistic regression for prevalent CVD and other dichotomous measures. Results: The ELISA CV was 9.3% at mean γ’ fibrinogen levels. Participants (mean age 60 years, 53.4% women) with prevalent CVD (0.297 ± 0.007 mg/ml; mean ± SE) had significantly higher mean concentrations than those without CVD (0.255 ± 0.002 mg/ml). There were significant (all p
Print ISSN:
0006-4971
Electronic ISSN:
1528-0020
Topics:
Biology
,
Medicine