Publication Date:
2007-11-16
Description:
TEL/ETV6 gene located at chromosome 12p13 is frequently rearranged in a variety of leukemia and solid tumor resulting in the formation of oncogenic chimeric protein product. TEL encodes a member of the ETS family of transcription factors and is also known to be essential for bone marrow hematopoiesis and vascular formation. To understand the role of TEL in erythropoiesis, we generated transgenic mice expressing TEL under the control of GATA1 promoter IE3.9int (Onodera et al, PNAS 1997) that is known to be active in erythroid-lineage hematopoiesis (GATA1-TEL transgenic mice). Although GATA1-TEL transgenic mice appeared healthy up to 18 months of age, Hb level was relatively higher in GATA1-TEL transgenic mice compared to non-transgenic littermates in 2 out of 4 transgenic lines (17.44±0.99 vs 16.52±0.97, 17.84±1.27 vs 17.06±0.75, p
Print ISSN:
0006-4971
Electronic ISSN:
1528-0020
Topics:
Biology
,
Medicine