Publication Date:
2014-12-06
Description:
The presence of certain cytogenetic abnormalities on plasma cells is considered as one of the most important prognostic factors for patients with newly diagnosed symptomatic myeloma. Non-hyperdiploid metaphase karyotype, the presence of del 17p, t(4;14) define high risk myeloma and have been associated with shorter survival either in patients who are treated with or without high dose therapy or novel agents (thalidomide, lenalidomide, bortezomib). Abnormalities in chromosome 1, and especially amplification of 1q21 (amp1q21) has been associated to a high risk of relapse and short survival in some studies but this has not been extensively validated. 1q21 locus contains CKS1B gene and its overexpression has been linked to 1q21 gains and adverse prognosis. We sought to evaluate the prognostic importance of amp1q21 in unselected myeloma patients who were treated in a single center (Department of Clinical Therapeutics, National and Kapodistrian University of Athens). The amp1q21 was evaluated using standard FISH after CD138 selection, according to EMN guidelines. The analysis included 324 patients with available cytogenetics and 26% had amp1q21. Patients with amp1q21 had more often hemoglobin
Print ISSN:
0006-4971
Electronic ISSN:
1528-0020
Topics:
Biology
,
Medicine