Publication Date:
2012-11-16
Description:
Abstract 2621 Current data on prognostic significance of extramedullary leukemia (EML) in general and for specific genetic subgroups in children with acute myeloid leukemia (AML) are limited and controversial. AML-BFM data from previous studies indicated that skin and testicular involvement were independent adverse prognostic factors in high-risk (HR) patients (core-binding factor [CBF] AML [=t(8;21) and inv16] patients were standard risk patients) (Creutzig, Blood (suppl)2001;98(11). This was supported by others for leukemia cutis (Dusenbery, J.Pediatr. Hematol. Oncol.2003). Orbital involvement, which is associated with t(8;21), was reported to be unfavorable in Turkish and Indian children. A Dutch study could not confirm the prognostic relevance of EML (Bisschop, Leukemia,2001). Therefore, we analyzed the data of pediatric CBF-AML and MLL gene-rearrangement AML (MLL-AML) patients
Print ISSN:
0006-4971
Electronic ISSN:
1528-0020
Topics:
Biology
,
Medicine