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Splenic marginal zone lymphoma (2003)

Franco, Vito ; Florena, Ada Maria ; Iannitto, Emilio

American Society of Hematology

In: Blood. 2003; 101(7): 2464-2472. Published 2003 Apr 01. doi: 10.1182/blood-2002-07-2216.

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Publication Date: 2003-04-01

Description: Splenic marginal zone lymphoma (SMZL) is a specific low-grade small B-cell lymphoma that is incorporated in the World Health Organization classification. Characteristic features are splenomegaly, moderate lymphocytosis with villous morphology, intrasinusoidal pattern of involvement of various organs, especially bone marrow, and relative indolent course. Tumor progression with increase of blastic forms and aggressive behavior are observed in a minority of patients. Molecular and cytogenetic studies have shown heterogeneous results probably because of the lack of standardized diagnostic criteria. To date, no definitive therapy has been established. Therapeutic options include treatment abstention, splenectomy, splenic irradiation, and chemotherapy.

Print ISSN: 0006-4971

Electronic ISSN: 1528-0020

Topics: Biology , Medicine

Published by American Society of Hematology

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