Publication Date:
1998-08-28
Description:
Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors, termed death receptors, on their surface. Death receptors detect the presence of extracellular death signals and, in response, they rapidly ignite the cell's intrinsic apoptosis machinery.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ashkenazi, A -- Dixit, V M -- New York, N.Y. -- Science. 1998 Aug 28;281(5381):1305-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. aa@gene.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9721089" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigens, CD/metabolism
;
Antigens, CD95/metabolism
;
*Apoptosis
;
Humans
;
Neoplasms/drug therapy/pathology
;
Receptors, Cell Surface/*metabolism
;
Receptors, TNF-Related Apoptosis-Inducing Ligand
;
Receptors, Tumor Necrosis Factor/*metabolism
;
Receptors, Tumor Necrosis Factor, Member 25
;
Receptors, Tumor Necrosis Factor, Type I
;
Signal Transduction
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
