Publication Date:
1998-07-17
Description:
Cell interactions mediated by Notch-family receptors have been implicated in the specification of tissue boundaries in vertebrate and insect development. Although Notch ligands are often widely expressed, tightly localized activation of Notch is critical for the formation of sharp boundaries. Evidence is presented here that the POU domain protein Nubbin contributes to the formation of a sharp dorsoventral boundary in the Drosophila wing. Nubbin represses Notch-dependent target genes and sets a threshold for Notch activity that defines the spatial domain of boundary-specific gene expression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Neumann, C J -- Cohen, S M -- New York, N.Y. -- Science. 1998 Jul 17;281(5375):409-13.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9665883" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Calcium-Binding Proteins
;
Drosophila/genetics/*growth & development/metabolism
;
*Drosophila Proteins
;
Enhancer Elements, Genetic
;
*Gene Expression Regulation
;
Genes, Insect
;
Homeodomain Proteins/genetics/metabolism/*physiology
;
Insect Proteins/genetics/physiology
;
Intercellular Signaling Peptides and Proteins
;
Intracellular Signaling Peptides and Proteins
;
Ligands
;
Membrane Proteins/genetics/*physiology
;
Mutation
;
*N-Acetylglucosaminyltransferases
;
Nuclear Proteins/genetics/physiology
;
POU Domain Factors
;
Proto-Oncogene Proteins/genetics/physiology
;
Receptors, Notch
;
Signal Transduction
;
Transcription Factors/genetics/metabolism/*physiology
;
Wings, Animal/*growth & development/metabolism
;
Wnt1 Protein
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
