Publication Date:
1997-12-31
Description:
The interleukin-1 receptor (IL-1R) signaling pathway leads to nuclear factor kappa B (NF-kappaB) activation in mammals and is similar to the Toll pathway in Drosophila: the IL-1R-associated kinase (IRAK) is homologous to Pelle. Two additional proximal mediators were identified that are required for IL-1R-induced NF-kappaB activation: IRAK-2, a Pelle family member, and MyD88, a death domain-containing adapter molecule. Both associate with the IL-1R signaling complex. Dominant negative forms of either attenuate IL-1R-mediated NF-kappaB activation. Therefore, IRAK-2 and MyD88 may provide additional therapeutic targets for inhibiting IL-1-induced inflammation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Muzio, M -- Ni, J -- Feng, P -- Dixit, V M -- New York, N.Y. -- Science. 1997 Nov 28;278(5343):1612-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of Michigan Medical School, Department of Pathology, Ann Arbor, MI 48109, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9374458" target="_blank"〉PubMed〈/a〉
Keywords:
Adaptor Proteins, Signal Transducing
;
Amino Acid Sequence
;
*Antigens, Differentiation
;
Carrier Proteins/metabolism
;
Cell Line
;
*Drosophila Proteins
;
Humans
;
Interleukin-1/*metabolism
;
Interleukin-1 Receptor-Associated Kinases
;
Molecular Sequence Data
;
Myeloid Differentiation Factor 88
;
NF-kappa B/metabolism
;
Protein Kinases/metabolism
;
Protein-Serine-Threonine Kinases/chemistry/metabolism
;
Proteins/chemistry/genetics/*metabolism
;
*Receptors, Immunologic
;
Receptors, Interleukin-1/*metabolism
;
Sequence Alignment
;
Sequence Homology, Amino Acid
;
*Signal Transduction
;
TNF Receptor-Associated Factor 6
;
Transfection
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
