Publication Date:
1996-09-20
Description:
Anandamide is an endogenous ligand for central cannabinoid receptors and is released after neuronal depolarization. Anandamide increased protein tyrosine phosphorylation in rat hippocampal slices and neurons in culture. The action of anandamide resulted from the inhibition of adenylyl cyclase and cyclic adenosine 3', 5'-monophosphate-dependent protein kinase. One of the proteins phosphorylated in response to anandamide was an isoform of pp125-focal adhesion kinase (FAK+) expressed preferentially in neurons. Focal adhesion kinase is a tyrosine kinase involved in the interactions between the integrins and actin-based cytoskeleton. Thus, anandamide may exert neurotrophic effects and play a role in synaptic plasticity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Derkinderen, P -- Toutant, M -- Burgaya, F -- Le Bert, M -- Siciliano, J C -- de Franciscis, V -- Gelman, M -- Girault, J A -- New York, N.Y. -- Science. 1996 Sep 20;273(5282):1719-22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉INSERM U 114, Chaire de Neuropharmacologie, College de France, 11 place Marcelin Berthelot, 75231 Paris cedex 05, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8781236" target="_blank"〉PubMed〈/a〉
Keywords:
Adenylyl Cyclase Inhibitors
;
Adenylyl Cyclases/metabolism
;
Amino Acid Sequence
;
Animals
;
Arachidonic Acid/pharmacology
;
Arachidonic Acids/*pharmacology
;
Cell Adhesion Molecules/*metabolism
;
Cell Line
;
Cells, Cultured
;
Cyclic AMP/metabolism
;
Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors/metabolism
;
Endocannabinoids
;
Focal Adhesion Kinase 1
;
Focal Adhesion Protein-Tyrosine Kinases
;
Hippocampus/drug effects/*enzymology
;
In Vitro Techniques
;
Molecular Sequence Data
;
Neuronal Plasticity/drug effects
;
Neurons/drug effects/*enzymology
;
Phosphorylation
;
Phosphotyrosine/metabolism
;
Polyunsaturated Alkamides
;
Prosencephalon
;
Protein-Tyrosine Kinases/*metabolism
;
Rats
;
Receptors, Cannabinoid
;
Receptors, Drug/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
