Publikationsdatum:
1996-06-21
Beschreibung:
The immunoglobulin alpha (Ig-alpha)-Ig-beta heterodimer is the signaling component of the antigen receptor complex on B cells (BCR) and B cell progenitors (pre-BCR). A mouse mutant that lacks most of the Ig-alpha cytoplasmic tail exhibits only a small impairment in early B cell development but a severe block in the generation of the peripheral B cell pool, revealing a checkpoint in B cell maturation that ensures the expression of a functional BCR on mature B cells. B cells that do develop demonstrate a differential dependence on Ig-alpha signaling in antibody responses such that a signaling-competent Ig-alpha appears to be critical for the response to T-independent, but not T-dependent, antigens.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Torres, R M -- Flaswinkel, H -- Reth, M -- Rajewsky, K -- New York, N.Y. -- Science. 1996 Jun 21;272(5269):1804-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Genetics, University of Cologne, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8650582" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Animals
;
Antibody Formation
;
Antigens/immunology
;
Antigens, CD/chemistry/immunology/*physiology
;
Antigens, CD79
;
Antigens, T-Independent/immunology
;
B-Lymphocytes/*cytology/*immunology
;
Bone Marrow Cells
;
Cell Lineage
;
Gene Rearrangement, B-Lymphocyte
;
Gene Targeting
;
Genes, Immunoglobulin
;
Hematopoietic Stem Cells/cytology/immunology
;
Lymphoid Tissue/cytology/immunology
;
Mice
;
Mice, Inbred C57BL
;
Receptors, Antigen, B-Cell/chemistry/immunology/*physiology
;
Signal Transduction
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
