Publication Date:
1996-06-07
Description:
Women are particularly susceptible to malaria during first and second pregnancies, even though they may have developed immunity over years of residence in endemic areas. Plasmodium falciparum-infected red blood cells (IRBCs) were obtained from human placentas. These IRBCs bound to purified chondroitin sulfate A (CSA) but not to other extracellular matrix proteins or to other known IRBC receptors. IRBCs from nonpregnant donors did not bind to CSA. Placental IRBCs adhered to sections of fresh-frozen human placenta with an anatomic distribution similar to that of naturally infected placentas, and this adhesion was competitively inhibited by purified CSA. Thus, adhesion to CSA appears to select for a subpopulation of parasites that causes maternal malaria.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fried, M -- Duffy, P E -- New York, N.Y. -- Science. 1996 Jun 7;272(5267):1502-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉U.S. Army Medical Research Unit-Kenya, Kisumu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8633247" target="_blank"〉PubMed〈/a〉
Keywords:
Adhesiveness
;
Adolescent
;
Adult
;
Animals
;
Antigens, CD36/metabolism
;
Chondroitin Lyases/pharmacology
;
Chondroitin Sulfates/*metabolism
;
Erythrocytes/metabolism/*parasitology
;
Extracellular Matrix Proteins/metabolism
;
Female
;
Humans
;
Malaria, Falciparum/*parasitology
;
Placenta/*parasitology
;
Plasmodium falciparum/*physiology
;
Pregnancy
;
Pregnancy Complications, Parasitic/*parasitology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
