Publication Date:
1996-06-07
Description:
The hippocampus has two major outputs: multisynaptic pathways to the cerebral cortex and a massive descending projection directly to the lateral septal part of the basal ganglia. Here it is shown that the descending output is organized in such a way that different hippocampal regions map in an orderly way onto hypothalamic systems mediating the expression of different classes of goal-oriented behavior. This mapping is characterized by a unidirectional hippocampo-lateral septal projection and then by bidirectional lateral septo-hypothalamic projections, all topographically organized. The connectional evidence predicts that information processing in different regions of the hippocampus selectively influences the expression of different classes of behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Risold, P Y -- Swanson, L W -- New York, N.Y. -- Science. 1996 Jun 7;272(5267):1484-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Program in Neural, Informational, and Behavioral Sciences, University of Southern California, Los Angeles 90089-2520, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8633241" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Autoradiography
;
Behavior, Animal
;
*Brain Mapping
;
Enkephalins/analysis
;
Glutamate Decarboxylase/analysis
;
Hippocampus/*anatomy & histology/*physiology
;
Hypothalamus/anatomy & histology/physiology
;
In Situ Hybridization
;
Memory/physiology
;
Neural Pathways
;
Neuropeptides/analysis
;
Pyramidal Cells/cytology/physiology
;
Rats
;
Septal Nuclei/*anatomy & histology/*physiology
;
Somatostatin/analysis
;
gamma-Aminobutyric Acid/analysis
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
