Publication Date:
1996-03-15
Description:
Diffusible factors of several protein families control appendage outgrowth and patterning in both insects and vertebrates. In Drosophila wing development, the gene decapentaplegic (dpp) is expressed along the anteroposterior compartment boundary. Early wingless (wg) expression is involved in setting up the dorsoventral boundary. Interaction between dpp- and wg-expressing cells promotes appendage outgrowth. Here, it is shown that optomotor-blind (omb) expression is required for distal wing development and is controlled by both dpp and wg. Ectopic omb expression can lead to the growth of additional wings. Thus, omb is essential for wing development and is controlled by two signaling pathways.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grimm, S -- Pflugfelder, G O -- New York, N.Y. -- Science. 1996 Mar 15;271(5255):1601-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Theodor-Boveri-Institut (Biozentrum), Lehrstuhl fur Genetik, Universitat Wurzburg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8599120" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
DNA-Binding Proteins/*genetics/physiology
;
Drosophila/*genetics/growth & development
;
*Drosophila Proteins
;
*Gene Expression Regulation, Developmental
;
Genes, Insect
;
Insect Hormones/*genetics/physiology
;
Larva/genetics/growth & development
;
Mutation
;
Nerve Tissue Proteins/*genetics/physiology
;
Phenotype
;
Proto-Oncogene Proteins/*genetics/physiology
;
Signal Transduction
;
*T-Box Domain Proteins
;
Wings, Animal/*growth & development
;
Wnt1 Protein
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
