Publication Date:
1996-03-15
Description:
Human foamy virus (HFV) is the prototype of the Spumavirus genus of Retroviridae. In all other retroviruses, the pol gene products, including reverse transcriptase, are synthesized as Gag-Pol fusion proteins and are cleaved to functional enzymes during viral budding or release. In contrast, the Pol protein of HFV is translated from a spliced messenger RNA and lacks Gag domains. Infectious HFV particles contain double-stranded DNA similar in size to full-length provirus, suggesting that reverse transcription has taken place in viral particles before new rounds of infection, reminiscent of hepadnaviruses. These data suggest that foamy viruses possess a replication pathway containing features of both retroviruses and hepadnaviruses but distinct from both.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yu, S F -- Baldwin, D N -- Gwynn, S R -- Yendapalli, S -- Linial, M L -- CA18282/CA/NCI NIH HHS/ -- F32 CA60357/CA/NCI NIH HHS/ -- HL53762/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1996 Mar 15;271(5255):1579-82.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8599113" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Base Sequence
;
Cells, Cultured
;
Cricetinae
;
Fusion Proteins, gag-pol/biosynthesis/genetics/metabolism
;
Gene Products, gag/biosynthesis/genetics
;
Gene Products, pol/*biosynthesis/genetics/metabolism
;
Genes, gag
;
Genes, pol
;
Genome, Viral
;
Hepatitis B virus/genetics/metabolism/physiology
;
Humans
;
Molecular Sequence Data
;
RNA Splicing
;
RNA, Viral/genetics
;
RNA-Directed DNA Polymerase/metabolism
;
Retroviridae/genetics/metabolism/physiology
;
Spumavirus/genetics/metabolism/*physiology
;
*Virus Replication
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
