Publication Date:
1996-03-29
Description:
The human ELL gene on chromosome 19 undergoes frequent translocations with the trithorax-like MLL gene on chromosome 11 in acute myeloid leukemias. Here, ELL was shown to encode a previously uncharacterized elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by polymerase at multiple sites along the DNA. Functionally, ELL resembles Elongin (SIII), a transcription elongation factor regulated by the product of the von Hippel-Lindau (VHL) tumor suppressor gene. The discovery of a second elongation factor implicated in oncogenesis provides further support for a close connection between the regulation of transcription elongation and cell growth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shilatifard, A -- Lane, W S -- Jackson, K W -- Conaway, R C -- Conaway, J W -- GM41628/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1996 Mar 29;271(5257):1873-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Program in Molecular and Cell Biology, Oklahoma Medical Research Foundation, Oklahoma City, 73104, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8596958" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Cloning, Molecular
;
DNA-Binding Proteins/chemistry/*genetics/metabolism
;
Genes, Tumor Suppressor
;
Histone-Lysine N-Methyltransferase
;
Humans
;
Leukemia/genetics
;
Molecular Sequence Data
;
Myeloid-Lymphoid Leukemia Protein
;
*Neoplasm Proteins
;
*Peptide Elongation Factors
;
*Proto-Oncogenes
;
RNA Polymerase II/*metabolism
;
RNA, Messenger/genetics/metabolism
;
Rats
;
Recombinant Proteins/metabolism
;
Transcription Factors/chemistry/*genetics/metabolism
;
Transcription, Genetic
;
Transcriptional Elongation Factors
;
Translocation, Genetic
;
von Hippel-Lindau Disease/genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
