Publication Date:
1996-02-16
Description:
In the brain of adult mice, cells that divide in the subventricular zone of the lateral ventricle migrate up to 5 millimeters to the olfactory bulb where they differentiate into neurons. These migrating cells were found to move as chains through a well-defined pathway, the rostral migratory stream. Electron microscopic analysis of serial sections showed that these chains contained only closely apposed, elongated neuroblasts connected by membrane specializations. A second cell type, which contained glial fibrillary acidic protein, ensheathed the chains of migrating neuroblasts. Thus, during chain migration, neural precursors moved associated with each other and were not guided by radial glial or axonal fibers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lois, C -- Garcia-Verdugo, J M -- Alvarez-Buylla, A -- HD32116/HD/NICHD NIH HHS/ -- NS28478/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1996 Feb 16;271(5251):978-81.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Rockefeller University, New York 10021, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8584933" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cell Differentiation
;
Cell Membrane/ultrastructure
;
Cell Movement
;
Cerebral Ventricles/*cytology
;
Glial Fibrillary Acidic Protein/analysis
;
Male
;
Mice
;
Microscopy, Electron
;
Mitosis
;
Neural Cell Adhesion Molecules/analysis
;
Neuroglia/chemistry/*cytology/physiology
;
Neurons/*cytology/ultrastructure
;
Olfactory Bulb/cytology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
