Publication Date:
1996-01-12
Description:
Development is buffered against unpredictable environmental and genetic effects. Here, a molecular genetic analysis of one type of developmental homeostasis, the establishment of thoracic segmental identity under the control of the Ultrabithorax (Ubx) gene in Drosophila melanogaster, is presented. Flies were artificially selected for differential sensitivity to the induction of bithorax phenocopies by ether vapor. The experiments demonstrated that increased sensitivity to ether correlated with a loss of expression of UBX in the third thoracic imaginal discs and that a significant proportion of the genetic variation for transcriptional stability can be attributed to polymorphism in the Ubx gene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gibson, G -- Hogness, D S -- New York, N.Y. -- Science. 1996 Jan 12;271(5246):200-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of Michigan, Ann Arbor 48109-1048, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8539619" target="_blank"〉PubMed〈/a〉
Keywords:
Alleles
;
Animals
;
Base Sequence
;
DNA-Binding Proteins/*genetics
;
*Drosophila Proteins
;
Drosophila melanogaster/drug effects/*genetics
;
Ether/pharmacology
;
Female
;
*Genes, Homeobox
;
*Genes, Regulator
;
Homeodomain Proteins/*genetics
;
Homeostasis
;
Linkage Disequilibrium
;
Male
;
Molecular Sequence Data
;
Mutation
;
Nucleic Acid Heteroduplexes
;
Phenotype
;
Polymerase Chain Reaction
;
*Polymorphism, Genetic
;
Selection, Genetic
;
*Transcription Factors
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
