Publication Date:
1994-02-18
Description:
Multimeric complexes of synaptic vesicle and terminal membrane proteins are important components of the neurotransmitter release mechanism. The csp gene of Drosophila encodes proteins homologous to synaptic vesicle proteins in Torpedo. Monoclonal antibodies demonstrate different distributions of isoforms at distinct subsets of terminals. Deletion of the csp gene in Drosophila causes a temperature-sensitive block of synaptic transmission, followed by paralysis and premature death.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zinsmaier, K E -- Eberle, K K -- Buchner, E -- Walter, N -- Benzer, S -- New York, N.Y. -- Science. 1994 Feb 18;263(5149):977-80.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉California Institute of Technology, Division of Biology, Pasadena 91125.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8310297" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Drosophila melanogaster/embryology/genetics/*physiology
;
Electroretinography
;
Gene Deletion
;
*Genes, Insect
;
Genes, Lethal
;
Genetic Complementation Test
;
Membrane Proteins/analysis/*genetics/physiology
;
Mutagenesis, Site-Directed
;
Nerve Tissue Proteins/analysis/*genetics/physiology
;
Phenotype
;
Photoreceptor Cells, Invertebrate/*physiology
;
Presynaptic Terminals/chemistry/*physiology
;
*Synaptic Transmission
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
