Publication Date:
1993-07-02
Description:
Regenerating optic nerves from fish produce a factor that is cytotoxic to oligodendrocytes. The cytotoxic factor is recognized by antibodies to interleukin-2 (IL-2) and has the apparent molecular size of a dimer of IL-2. An enzyme, identified as a nerve transglutaminase, was purified from regenerating optic nerves of fish and was found to catalyze dimerization of human IL-2. The dimerized IL-2, unlike monomeric IL-2, is cytotoxic to oligodendrocytes from rat brain in culture. The results suggest that posttranslational modification of a cytokine can alter its activity. Under conditions in which oligodendrocytes inhibit neuronal regeneration, dimerization of IL-2 might provide a mechanism to permit nerve growth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eitan, S -- Schwartz, M -- New York, N.Y. -- Science. 1993 Jul 2;261(5117):106-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8100369" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Animals, Newborn
;
Brain/cytology
;
Cell Survival/drug effects
;
Cells, Cultured
;
Fishes
;
Interleukin-2/*metabolism/pharmacology
;
Molecular Sequence Data
;
*Nerve Regeneration
;
Oligodendroglia/cytology/*drug effects
;
Optic Nerve/enzymology/*physiology
;
Transglutaminases/isolation & purification/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
