Publication Date:
1994-11-18
Description:
Muscle enhancer factor-2A (MEF2A), a member of the MADS family, induced myogenic development when ectopically expressed in clones of nonmuscle cells of human clones, a function previously limited to the muscle basic helix-loop-helix (bHLH) proteins. During myogenesis, MEF2A and bHLH proteins cooperatively activate skeletal muscle genes and physically interact through the MADS domain of MEF2A and the three myogenic amino acids of the muscle bHLH proteins. Thus, skeletal myogenesis is mediated by two distinct families of mutually inducible and interactive muscle transcription factors, either of which can initiate the developmental cascade.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaushal, S -- Schneider, J W -- Nadal-Ginard, B -- Mahdavi, V -- New York, N.Y. -- Science. 1994 Nov 18;266(5188):1236-40.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cardiology, Children's Hospital, Harvard Medical School, Boston, MA 02115.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7973707" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Base Sequence
;
Binding Sites
;
Cell Differentiation
;
Cell Line
;
DNA/metabolism
;
DNA-Binding Proteins/genetics/*metabolism
;
*Gene Expression Regulation
;
Genes, Reporter
;
Haplorhini
;
Helix-Loop-Helix Motifs
;
Humans
;
MADS Domain Proteins
;
MEF2 Transcription Factors
;
Mice
;
Molecular Sequence Data
;
Muscle, Skeletal/*cytology/metabolism
;
MyoD Protein/biosynthesis/*metabolism
;
Myogenic Regulatory Factors
;
Myogenin/biosynthesis/genetics/metabolism
;
Transcription Factors/genetics/*metabolism
;
Transfection
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
