Publication Date:
1995-06-02
Description:
Only so-called "professional" antigen-presenting cells (APCs) of hematopoietic origin are believed capable of inducing T lymphocyte responses. However, fibroblasts transfected with viral proteins directly induced antiviral cytotoxic T lymphocyte responses in vivo, without involvement of host APCs. Fibroblasts induced T cells only in the milieu of lymphoid organs. Thus, antigen localization affects self-nonself discrimination and cell-based vaccine strategies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kundig, T M -- Bachmann, M F -- DiPaolo, C -- Simard, J J -- Battegay, M -- Lother, H -- Gessner, A -- Kuhlcke, K -- Ohashi, P S -- Hengartner, H -- New York, N.Y. -- Science. 1995 Jun 2;268(5215):1343-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Experimental Immunology, University of Zurich, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7761853" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigen-Presenting Cells/*immunology
;
Cytotoxicity, Immunologic
;
Fibroblasts/*immunology
;
Glycoproteins/immunology
;
Histocompatibility Antigens Class I/immunology
;
L Cells (Cell Line)
;
Lymphocytic Choriomeningitis/immunology
;
Lymphocytic choriomeningitis virus/*immunology
;
Lymphoid Tissue/*immunology
;
Mice
;
Mice, Inbred C57BL
;
Neoplasms/immunology
;
T-Lymphocytes, Cytotoxic/*immunology
;
Transfection
;
Tumor Cells, Cultured
;
Viral Proteins/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
