Publication Date:
1995-04-28
Description:
The effects of neurotrophins on several forms of neuronal degeneration in murine cortical cell cultures were examined. Consistent with other studies, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 all attenuated the apoptotic death induced by serum deprivation or exposure to the calcium channel antagonist nimodipine. Unexpectedly, however, 24-hour pretreatment with these same neurotrophins markedly potentiated the necrotic death induced by exposure to oxygen-glucose deprivation or N-methyl-D-aspartate. Thus, certain neurotrophins may have opposing effects on different types of death in the same neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koh, J Y -- Gwag, B J -- Lobner, D -- Choi, D W -- NS 30337/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1995 Apr 28;268(5210):573-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for the Study of Nervous System Injury, Washington University School of Medicine, St. Louis, MO 63110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7725105" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Apoptosis/drug effects
;
Brain-Derived Neurotrophic Factor
;
Calcium/metabolism
;
Cell Death/drug effects
;
Cells, Cultured
;
Cerebral Cortex/cytology
;
Dizocilpine Maleate/pharmacology
;
Mice
;
N-Methylaspartate/pharmacology
;
Necrosis
;
Nerve Degeneration/*drug effects
;
Nerve Growth Factors/*pharmacology
;
Nerve Tissue Proteins/pharmacology
;
Neurons/*cytology/drug effects/pathology
;
Neurotrophin 3
;
Quinoxalines/pharmacology
;
Receptors, AMPA/antagonists & inhibitors
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
