Publication Date:
1993-11-05
Description:
Stimulation of T cell proliferation generally requires two signals: The first signal is provided by the T cell receptor binding to antigen, and the second signal or costimulus is provided by a different receptor-ligand interaction. In mouse and human, the CD28-B7 interaction has been identified as a source of costimulatory signals. We have identified a cell surface molecule (GL1) that is distinct from B7 and abundantly expressed on activated B cells. On activated B cells GL1, rather than B7, is the predominant ligand for the T cell-activation molecule CTLA-4. GL1 provides a critical signal for T cell-dependent responses in vitro and in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hathcock, K S -- Laszlo, G -- Dickler, H B -- Bradshaw, J -- Linsley, P -- Hodes, R J -- New York, N.Y. -- Science. 1993 Nov 5;262(5135):905-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7694361" target="_blank"〉PubMed〈/a〉
Keywords:
Abatacept
;
Animals
;
Antibodies, Monoclonal
;
Antigens, CD/metabolism
;
Antigens, CD18
;
Antigens, CD80/immunology/*metabolism
;
Antigens, Differentiation/*metabolism
;
Antigens, Surface/immunology/*metabolism
;
B-Lymphocytes/*immunology
;
CHO Cells
;
CTLA-4 Antigen
;
Cricetinae
;
*Immunoconjugates
;
Interleukin-2/biosynthesis
;
*Lymphocyte Activation
;
Mice
;
T-Lymphocytes/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
