Publication Date:
1995-09-15
Description:
Macrophage inflammatory protein-1 alpha (MIP-1 alpha) is a chemokine that has pro-inflammatory and stem cell inhibitory activities in vitro. Its biologic role in vivo was examined in mice in which the gene encoding MIP-1 alpha had been disrupted. Homozygous MIP-1 alpha mutant (-/-) mice were resistant to Coxsackievirus-induced myocarditis seen in infected wild-type (+/+) mice. Influenza virus-infected -/- mice had reduced pneumonitis and delayed clearance of the virus compared with infected +/+ mice. The -/- mice had no overt hematopoietic abnormalities. These results demonstrate that MIP-1 alpha is an important mediator of virus-induced inflammation in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cook, D N -- Beck, M A -- Coffman, T M -- Kirby, S L -- Sheridan, J F -- Pragnell, I B -- Smithies, O -- GM20069/GM/NIGMS NIH HHS/ -- HL37001/HL/NHLBI NIH HHS/ -- R29HL46195/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1995 Sep 15;269(5230):1583-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, University of North Carolina, Chapel Hill 27599-7525, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7667639" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antibodies, Viral/blood
;
B-Lymphocytes/immunology
;
Base Sequence
;
Chemokine CCL4
;
Coxsackievirus Infections/*immunology/virology
;
Cytokines/genetics/*physiology
;
*Enterovirus B, Human/growth & development/immunology
;
Gene Targeting
;
Hematopoiesis
;
*Influenza A virus/growth & development/immunology
;
Lymphocyte Activation
;
Macrophage Inflammatory Proteins
;
Mice
;
Mice, Inbred C57BL
;
Molecular Sequence Data
;
Monokines/genetics/*physiology
;
Myocarditis/*immunology/virology
;
Neutralization Tests
;
Orthomyxoviridae Infections/*immunology/virology
;
Stem Cells
;
T-Lymphocytes/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
