Publication Date:
1995-08-04
Description:
By presenting antigenic peptides to T lymphocytes, major histocompatibility complex (MHC) class I molecules play important roles in the human immune system. Knowledge is limited on the evolutionary history of human MHC class I-related molecules. An expressed class I gene, MR1, has now been identified on human chromosome 1q25, outside the MHC. In contrast to other known human divergent class I genes, MR1 encodes peptide-binding domains similar to those encoded by human leukocyte antigen (HLA) class I genes on chromosome 6 and by nonmammalian classical MHC class I genes. This gene may thus contribute to understanding the evolution of the MHC.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hashimoto, K -- Hirai, M -- Kurosawa, Y -- New York, N.Y. -- Science. 1995 Aug 4;269(5224):693-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Comprehensive Medical Science, Fujita Health University, Aichi, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7624800" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Base Sequence
;
Biological Evolution
;
Chromosome Mapping
;
*Chromosomes, Human, Pair 1
;
Chromosomes, Human, Pair 6
;
*Genes, MHC Class I
;
Histocompatibility Antigens Class I/chemistry/*genetics
;
Humans
;
*Major Histocompatibility Complex
;
Molecular Sequence Data
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
