Publication Date:
1994-05-06
Description:
Slug, a vertebrate gene encoding a zinc finger protein of the Snail family, is expressed in the neural crest and in mesodermal cells emigrating from the primitive streak. Early chick embryos were incubated with antisense oligonucleotides to chick Slug. These oligonucleotides specifically inhibit the normal change in cell behavior that occurs at the two sites in the emerging body plan in which the gene is expressed. This change, which is the transition from epithelial to mesenchymal character, occurs at the formation of mesoderm during gastrulation and on emigration of the neutral crest from the neural tube.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nieto, M A -- Sargent, M G -- Wilkinson, D G -- Cooke, J -- New York, N.Y. -- Science. 1994 May 6;264(5160):835-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Instituto Cajal, Madrid, Spain.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7513443" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Antigens, CD/analysis
;
Antigens, CD57
;
Antigens, Differentiation, T-Lymphocyte/analysis
;
Base Sequence
;
Blastoderm/cytology
;
Cell Movement
;
Central Nervous System/*embryology
;
Chick Embryo
;
Gastrula/*cytology
;
Gene Expression
;
In Situ Hybridization
;
Mesoderm/*cytology
;
Molecular Sequence Data
;
Neural Crest/cytology/immunology
;
Oligonucleotides, Antisense/pharmacology
;
Transcription Factors/chemistry/*genetics
;
Transcription, Genetic
;
Zinc Fingers/*genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
