Publication Date:
1978-02-24
Description:
In rats, as reported in humans, chlordecone (Kepone) is excreted predominantly in the feces. Cholestyramine, an anion exchange resin, binds chlordecone in rat intestine, increases its excretion into the feces, and decreases its content in the tissues. The resin appears to offer a practical method for treating chronic poisoning with this and possibly with other lipophilic toxins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boylan, J J -- Egle, J L -- Guzelian, P S -- New York, N.Y. -- Science. 1978 Feb 24;199(4331):893-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/74852" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Bile/metabolism
;
Chlordecone/metabolism/*poisoning
;
Cholestyramine Resin/*therapeutic use
;
Feces/metabolism
;
Inactivation, Metabolic
;
Insecticides/*poisoning
;
Male
;
Rats
;
Tissue Distribution
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
