Publication Date:
1981-02-27
Description:
Negative-chemical-ionization mass spectral screening of extracts of human seminal plasma has revealed a presence of a Cl7 ion cluster at a mass-to-charge ratio (m/z) of 463 in a significant number of the samples examined (34 out of 123). Experiments with different gases used to generate the negative-chemical-ionization plasma indicated that the ion at m/z 463 was a chloride adduca of a Cl6 molecule with a mass of 428 daltons. Negative-chemical-ionization mass measurement with ions from the iodoform mass spectrum used as reference peaks gave a mass of 427.882 daltons; C9H15PCl6 has a molecular weight of 427.883. Extraction of polyurethane foam with toluene produced an extract that consistently gave a negative-chemical-ionization spectrum containing an intense Cl7ion at m/z463. The component producing ion was isolated, and its proton nuclear magnetic resonance spectrum confirmed that it was tris (1,3-dichloro-2-propyl)phosphate, a mutagenic flame retardant. The negative-chemical-ionization screening evidence suggests that this flame retardant or its isomer tris(2,3-dichloro-l-propyl)phosphate, or both, are absorbved into the body from formulations in which they are used as flame retardants. Remedial action seems indicated to reduce human exposure to these compunds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hudec, T -- Thean, J -- Kuehl, D -- Dougherty, R C -- ES-79-2/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 1981 Feb 27;211(4485):951-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7466368" target="_blank"〉PubMed〈/a〉
Keywords:
Environmental Exposure
;
Flame Retardants/*analysis
;
Humans
;
Hydrocarbons, Chlorinated/analysis
;
Male
;
Mass Spectrometry
;
Mutagens/*analysis
;
Organophosphorus Compounds/*analysis
;
Semen/*analysis
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
